Summary
This webinar discusses the application of next-generation sequencing (NGS) in analyzing cell-free circulating tumor DNA in cancer patients for precision medicine. Dr. Clifford explains the workflow from DNA isolation to data analysis, emphasizing the identification of somatic mutations and therapeutic targets through NGS. The presentation also covers challenges like low-frequency mutations, quality control, and the importance of interpreting actionable mutations for clinical relevance in circulating tumor DNA analysis using NGS. Overall, the talk provides valuable insights into the potential of NGS technology in advancing precision medicine applications.
Introduction to NGS in Clinical Research
Webinar series on next-generation sequencing in clinical research presented by Krishnan Alan Pullum, the moderator, setting the stage for the event and making announcements.
Speaker Introduction - Dr. Clifford
Introduction of Dr. Clifford, the speaker for the webinar, who is the Director of the UC Davis Comprehensive Cancer Center Genomics and Molecular Medicine.
NGS Applications in Clinical Research
Dr. Clifford's presentation on the use of next-generation sequencing for analyzing cell-free circulating tumor DNA in cancer patients and its implications for precision medicine.
NGS Workflow Overview
Detailed explanation of the workflow involved in next-generation sequencing of circulating tumor DNA, including DNA isolation, library preparation, sequencing, and data analysis.
Mutation Analysis and Clinical Relevance
Discussion on identifying somatic mutations, actionable genes, and potential therapeutic targets in circulating tumor DNA through NGS analysis.
Data Analysis and Interpretation
Insights into variant calling, quality control, analysis of NGS data, visualization, and the importance of interpreting actionable mutations for clinical relevance.
Challenges and Solutions in NGS Analysis
Addressing challenges such as low-frequency mutations, false positives, and verification methods in circulating tumor DNA analysis using NGS technology.
Conclusion and Acknowledgments
Summary of key findings, future directions, and acknowledgments for the work done in NGS analysis of circulating tumor DNA, paving the way for precision medicine applications.
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