Towards Extinction of Not Otherwise Specified:WHO Head & Neck Tumours Classification 5th edition - I

The host introduces the podcast episode featuring Dr. Ler Thompson discussing updates on head and neck tumors. The episode is part one of a multi-part talk.

Dr. Thompson discusses the World Health Organization classification, its evolution, and the importance of standardized approaches and terminology in pathology.

The use of virtual slides for diagnosis and the integration of AI technology in pathology practice are highlighted, emphasizing the benefits of digital platforms.

New entities in pathology, such as Sclerosing Polycystic Adenoma, Mucinous Oncocytoma, and Squamous Intraepithelial Neoplasia, are discussed along with updates on existing diagnostic categories.

The significance of high-risk HPV-related lesions, the role of p16 immunohistochemistry, and the challenges in diagnosis and classification of these tumors are explained.

Detailed descriptions of histopathological features, including cellular characteristics, growth patterns, and imunohistochemical markers used for tumor evaluation are presented for various entities.

Clinical relevance and diagnostic challenges of tumors in specific anatomical locations, such as the oral cavity and sinonasal tract, including updates in classification and terminology are discussed.

Discussing the prognosis of patients with HPV Association and the identification of INSM1 positive tumors.

Exploring the classification and characteristics of odontogenic tumors based on their association with hard tissues.

Highlighting the features of surgical ciliated cysts, emphasizing their histological distinction and unique architecture.

Discussing the unique features of TFCP2 rearranged rhabdomyosarcoma and its classification in the skull base region.

Exploring the characteristics and diagnostic challenges of middle ear neuroendocrine tumors, highlighting their distinct features and immunohistochemical findings.

Discussing the identification and diagnostic features of secretory carcinoma, emphasizing its recognition in histopathological evaluation.

Overviewing the management and characteristics of intercalated duct adenomas, highlighting the surgical excision as the main management approach.

Distinguishing between neuroendocrine tumors and carcinomas, emphasizing the importance of accurate classification for appropriate management and research purposes.

Discussing the relevance of a global approach in the diagnosis and classification of neuroendocrine tumors, emphasizing the key role of morphology and immunohistochemistry.