Is Aging Reversible? A Scientific Look with David Sinclair | David Sinclair | TEDxBoston


Summary

The video delves into gerontology, emphasizing recent advancements that challenge the natural progression of aging and seek to extend human lifespan by treating aging as a disease. It explores how genes like sirtuins and AMPK can control aging, responding to external factors like exercise and fasting. The discussion also touches on epigenetics and reprogramming aging through genetic modifications, showcasing potential breakthroughs in reversing the aging process and enhancing cognitive abilities in humans.


Revolution in Longevity Science

The speaker discusses the field of gerontology, also known as longevity science, highlighting the significant developments in the past 25 years and the possibilities it opens up for extending human lifespan.

Redefining Aging

The speaker challenges the notion of aging as a natural process and advocates for prolonging human life and combating age-related diseases like Alzheimer's, viewing aging as a disease in itself.

The Role of Sirtuins and AMPK

Exploration of the sirtuins and AMPK genes in controlling aging and longevity by responding to adversity, exercise, and fasting to promote healthier and longer life spans.

Epigenetics and Aging

Discussion on epigenetics and its role in aging, including the impact of DNA methylation patterns and the importance of maintaining youthful epigenetic information for cellular health and longevity.

Reprogramming Aging

Introduction of the concept of reprogramming aging through genetic modifications and the potential to reverse the aging process in mice, highlighting the role of NAD boosters and sirtuin activation.

Future Possibilities in Longevity Science

Exploration of the groundbreaking research in reversing aging, indicating the potential for resetting the human body's age and the transformative impact it may have on extending lifespan and cognitive abilities.

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